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You are here:Home » Antibodies » Abs to DEAD Box Proteins » Anti -MDA5 (Melanoma Differentiation-Associated Protein 5, DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide, Helicard, Hlcd, Helicase with 2 CARD Domains, IDDM19, Interferon-induced with Helicase C Domain Protein 1, Interferon-induced Helicase C Domain-containing P

Anti -MDA5 (Melanoma Differentiation-Associated Protein 5, DEAD/H (Asp-Glu-Ala-Asp/His)
Box Polypeptide, Helicard, Hlcd, Helicase with 2 CARD Domains, IDDM19, Interferon-induced
with Helicase C Domain Protein 1, Interferon-induced Helicase C Domain-containing P

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Affinity Purified
The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses . Like the toll-like receptor 3 (TLR3), the melanoma differentiation-associated protein 5 (MDA5) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. MDA5, a member of the DEAD/DEAH-box RNA helicase family, consists of an amino-terminal caspase recruitment domain (CARD) and a carboxyl-terminal RNA helicase domain similar to that of the related protein RIG-1. When stimulated by dsRNA, MDA5 recruits the adaptor protein VISA and ultimately causes the activation of IRF-3 and NF- B. MDA5 and RIG-1 recognize different types of dsRNA, with MDA5 recognizing poly (I:C). MDA5-null mice were highly susceptible to infection with picornaviruses, which possess such sequences, demonstrating the importance of MDA5 in innate immunity.
Catalog #M2772-75H
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:16,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceMouse
Concentration~0.5mg/ml
FormSupplied as a liquid in Tris saline, 0.02% sodium azide, pH7.3, 0.5% BSA.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide corresponding to C-KQKLRNNDLKKQN, from the internal region of MDA5/IFIH1 (NP_082111.1).
SpecificityRecognizes MDA5/IFIH1. Sequence homology: mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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