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Abs to Multi Drug Resistance (MDR)
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Anti -MDR Protein (MRP1, Multidrug resistance-associated protein 1, ABCC1, ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter)
Anti -MDR Protein (MRP1, Multidrug resistance-associated protein 1, ABCC1, ATP-binding
cassette sub-family C member 1, Leukotriene C(4) transporter)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Purified |
IP IC FC |
|
| MRP1 is a 190kD transmembrane phosphoglycoprotein overexpressed in various human multidrug resistant tumor cell lines and tumors . | | | Catalog # | M2825-12M | | Applications | | | Suitable for use in Immunocytochemistry, Flow Cytometry, Immunoprecipitation and Transport inhibition. Not recommended for use in Western Blot. Other applications have not been tested. | | Recommended Dilutions | Immunocytochemistry: use on paraformaldehyde (0.5% in PBS) fixed cytospin preparations | | Flow Cytometry: 0.2-1ug/ml after fixing cells in 0.5% paraformaldehyde, followed by suitable fluorescent tagged anti-mouse reagent (6) | | Transport Inhibition: Inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vessicles. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 6D559 | | Host | Mouse | | Source | Human | | Concentration | ~0.04mg/ml | | Form | Supplied as a liquid in PBS, 0.7% BSA, 0.1% sodium azide. | | Purity | Purified | | Immunogen | Non-denatured membranes prepared from the human small cell lung cancer cell line H69AR, which highly overexpresses MRP1. | | Specificity | Recognizes a conformation-dependent internal epitope (aa617-932) of human MRP1 overexpressed in various human non-P-glycoprotein MDR tumor cell lines. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, or mouse MRP gene products. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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