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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -MDR Protein (MRP1, Multidrug resistance-associated protein 1, ABCC1, ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter)

Anti -MDR Protein (MRP1, Multidrug resistance-associated protein 1, ABCC1, ATP-binding
cassette sub-family C member 1, Leukotriene C(4) transporter)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IP IC FC
MRP1 is a 190kD transmembrane phosphoglycoprotein overexpressed in various human multidrug resistant tumor cell lines and tumors .
Catalog #M2825-12M
Applications
Suitable for use in Immunocytochemistry, Flow Cytometry, Immunoprecipitation and Transport inhibition. Not recommended for use in Western Blot. Other applications have not been tested.
Recommended DilutionsImmunocytochemistry: use on paraformaldehyde (0.5% in PBS) fixed cytospin preparations
Flow Cytometry: 0.2-1ug/ml after fixing cells in 0.5% paraformaldehyde, followed by suitable fluorescent tagged anti-mouse reagent (6)
Transport Inhibition: Inhibits the ATP-dependent transport activity of MRP1 in inside-out membrane vessicles.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No6D559
HostMouse
SourceHuman
Concentration~0.04mg/ml
FormSupplied as a liquid in PBS, 0.7% BSA, 0.1% sodium azide.
PurityPurified
ImmunogenNon-denatured membranes prepared from the human small cell lung cancer cell line H69AR, which highly overexpresses MRP1.
SpecificityRecognizes a conformation-dependent internal epitope (aa617-932) of human MRP1 overexpressed in various human non-P-glycoprotein MDR tumor cell lines. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, or mouse MRP gene products.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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