Anti -MDR1 (P-Glycoprotein, Pgp170, MRP1, Multi Drug Resistance Associated Protein, ABCB1,
ATP-binding cassette, sub-family B (MDR/TAP), member 1, ABC20, CD243, CD243 antigen, CLCS,
GP170)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
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| CD243, also known as MDR1 (multi-drug resistance protein 1) and P-glycoprotein, is a 170kD membrane-associated protein which functions as an ATP-dependent drug efflux pump with broad substrate specificity. CD243 is highly expressed in the kidney, liver, adrenal gland and intestine, suggesting a primary role in the secretion of metabolites into bile, urine and the lumen of the intestinal tract. CD243 also prevents the accumulation of toxic compounds in critical organs such as the brain, gonads, and bone marrow, and also functions in the placenta to protect the fetus. CD243 is rapidly up-regulated by chemotherapeutic drugs and is a well established mediator of multidrug resistance. | | | Catalog # | M2825-14E | | Applications | Suitable for use in Immunohistochemistry (paraffin). Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 20ug/ml | | Requires antigen retrieval using heat treatment for 20 minutes prior to staining of paraffin sections. Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, pH 7.7, 0.09% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to cytoplasmic domain of human CD243, conjugated to KLH. | | Specificity | Recognizes human MDR1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -MDR1 (P-Glycoprotein, Pgp170, MRP1, Multi Drug Resistance Associated Protein, ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1, ABC20, CD243, CD243 antigen, CLCS, GP170) |
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