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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -MDR1 (Multi Drug Resistance Protein 1, ABC20, ATP Binding Cassette Subfamily B (MDR/TAP) Member 1, ABCB1, CD243, CLCS, GP170, P-Glycoprotein, P-gp, P Glycoprotein 1, PGY1)

Anti -MDR1 (Multi Drug Resistance Protein 1, ABC20, ATP Binding Cassette Subfamily B
(MDR/TAP) Member 1, ABCB1, CD243, CLCS, GP170, P-Glycoprotein, P-gp, P Glycoprotein 1,
PGY1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
P-glycoprotein, the product of the MDR1 (Multidrug Resistance 1) gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of the P-glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine suggesting that the primary role of P-glycoprotein is in the normal secretion of physiological metabolites and ingesting chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P-glycoprotein have also been reported in the multidrug-resistant cell lines and in colon, endometrial, ovarian, breast tumors, sarcomas and lymphomas.
Catalog #M2825-14N
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry: Frozen and formalin-fixed, paraffin-embedded tissue sections. Epitope retreival is required using citrate buffer. See protocol.
Optimal dilutions to be determined by the researcher.
Positive ControlLiver/colon
Expected Staining PatternMembrane
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No6A119
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.1% sodium azide.
PurityTissue culture supernatant
ImmunogenMulti-Drug Resistant Chinese hamster cell line (CHrC5)
SpecificityRecognizes human Multi-Drug Resistance 1.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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