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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -MDR1 (Multi Drug Resistance Protein 1, ABC20, ATP Binding Cassette Subfamily B (MDR/TAP) Member 1, ABCB1, CD243, CLCS, GP170, P-Glycoprotein, P-gp, P Glycoprotein 1, PGY1)

Anti -MDR1 (Multi Drug Resistance Protein 1, ABC20, ATP Binding Cassette Subfamily B
(MDR/TAP) Member 1, ABCB1, CD243, CLCS, GP170, P-Glycoprotein, P-gp, P Glycoprotein 1,
PGY1)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Purified IH
P-glycoprotein, the product of the MDR1 (Multidrug Resistance 1) gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of the P-glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P-glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine, and the lumen of the intestinal tract. Elevated levels of P-glycoprotein have also been reported in the multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas, leukemias, and lymphomas
Catalog #M2825-14Q
ApplicationsSuitable for use in Immunohistochemistry. Other applications have not been tested.
Recommended DilutionImmunohistochemistry: Frozen and formalin-fixed, paraffin-embedded tissue sections.
Optimal dilutions to be determined by the researcher.
Positive Control Human liver or human colon
Expected Staining Pattern: Membrane
Epitope Retrieval: Not Required
Enzyme Digestion: Not Required
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No6A122
HostMouse
ConcentrationNot determined
FormSupplied as a liquid in PBS, pH 7.4, and 1% BSA with 0.1% sodium azide
PurityPurified from mouse ascites
ImmunogenMultidrug resistant CHO cells
SpecificityRecognizes Multidrug Resistance 1
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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