Anti -MDR1 (Multidrug Resistance Protein 1, ABC20, ATP-binding Cassette Sub-family B
Member 1, ABCB1, CD243, CLCS, GP170, MGC163296, P-glycoprotein 1, P-GP, PGY1)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
IH |
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| The Human multidrug resistance gene MDR1 encodes a membrane-bound protein, referred to as P-glycoprotein that acts as a pump to extrude toxins from cells. The 3' untranslated region (3'UTR) of the Human MDR1 mRNA is very AU-rich (70%). MDR1 is a member of the super family of ATP-binding cassette (ABC) transporters. MDR1 is a member of the MDR/TAP subfamily. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. It is expressed in Human liver, kidney, small intestine and brain. It is localized to Human chromosome 7q21.1. | | | Catalog # | M2825-14Y | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 20ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Adrenal, cortex | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | As reported | | Form | Supplied as a liquid in PBS, pH 7.7, 0.1% sodium azide. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the cytoplasmic domain of human MDR1 (KLH). | | Specificity | Recognizes human MDR1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | ATP-binding Cassette, Sub-family B (MDR/TAP), Member 1, EC=3.6.3.44 |
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Download Specifications for Anti -MDR1 (Multidrug Resistance Protein 1, ABC20, ATP-binding Cassette Sub-family B Member 1, ABCB1, CD243, CLCS, GP170, MGC163296, P-glycoprotein 1, P-GP, PGY1) |
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