Anti -MDR3 P-glycoprotein (Multidrug Resistance Protein 3, ABC21, ATP-binding Cassette
Sub-family B (MDR/TAP) Member 4, ABCB4, GBD1, PFIC-3, P-glycoprotein 3, PGY3)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
B IH IC FC |
|
| The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function. | | | Catalog # | M2825-18R | | Applications | Suitable for use in Immunocytochemistry, Immunohistochemistry, Western Blot and Flow Cytometry. Other applications not tested. | | Recommended Dilution | Immunocytochemistry: 1:20-1:50 on acetone fixed cytospin preparations. | | Immunohistochemistry: 1:20 on acetone fixed frozen sections. Does not work well on formaldehyde-fixed paraffin-embedded human tissues. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Clone No | P3II-26 | | Host | Mouse | | Concentration | Not determined | | Form | Supplied as a liquid in 0.7% BSA, 0.1% sodium azide. | | Purity | Supernatant | | Immunogen | Fusion protein consisting of a fragment of MDR3 P-glycoprotein corresponding to aa629-692. | | Specificity | Recognizes an internal epitope of MDR3 P-glycoprotein. Does not crossreact with human MDR1 P-glycoprotein. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | EC=3.6.3.44, MDR2 |
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