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You are here:Home » Antibodies » Antibodies-Multi Drug Resistance (MDR) » Anti -MDR5 (MRP5, Multi Drug Resistance Associated Protein)

Anti -MDR5 (MRP5, Multi Drug Resistance Associated Protein)


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Clone Host Grade Applications
Monoclonal Rat Supernatant B IH IC FC
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Catalog #M2825-20B
ApplicationsSuitable for use in Flow cytometry, Immunocytochemistry, Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended Dilutions
Flow Cytometry: Weak, cell permeabilization required.
Immunocytochemistry: 1:20-1:50. Use on acetone fixed cytospin preparations.
Immunohistochemistry (Frozen sections, weak): 1:20. Use on acetone fixed frozen sections followed by incubation with rabbit anti-rat Ig and a monoclonal rat APAAP complex. Alternatively, after incubation with M2825-20B and washing, slides can be incubated with biotinylated rabbit anti-rat Ig and streptavidin conjugated to horseradish peroxidase.
Western Blot: 1:20-1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50% glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
Clone No6D572
ConcentrationNot Determined
FormSupplied as a liquid in 0.7% BSA, 0.1% sodium azide.
ImmunogenRecombinant human MRP5 (multidrug resistance-associated protein 5) (aa 82-168).
SpecificityRecognizes an internal epitope of human MRP5. Does not cross-react with human P-glycoprotein, MDR3 P-glycoprotein, MRP1, MRP2 (cMOAT) or MRP3.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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