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You are here:Home » Molecular Biology » MB-Protein Kinase Inhibitors » MEK1, 2 Inhibitor (U0126, Bis[amino[(2-aminophenyl)thio]methylene] Butanedinitrile)

MEK1, 2 Inhibitor (U0126, Bis[amino[(2-aminophenyl)thio]methylene] Butanedinitrile)


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Selective inhibitor of the mitogen-activated protein kinase kinases, MEK-1 and MEK-2, with 100-fold higher potency than PD 98059, but is, at most, a weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4. U0126 is an inhibitor of AP-1 transactivation in cell-based reporter assays.
Catalog #M2865-50A
In aqueous and certain organic solvents M2865-50A exists as an equilibrium mixture of 2 isomers which cannot be permanently separated. The 2 individual isomers have equivalent biological activity because they give rise to the same equilibrium mixture of isomes in aqueous solutions.
SolubilitySoluble in DMSO at 200mg/ml. Very poorly soluble in ethanol and water. Maximum solubility in plain water is estimated to be about 10-50uM.
Melting Point156-159ºC
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number109511-58-2
Molecular FormulaC18H16N6S2
Molecular Weight380.49
Purity~99% (HPLC, TLC)
FormSupplied as a white powder
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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