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You are here:Home » Antibodies » Abs to Transcription Factors, Zinc (Ring) Finger » Anti -MARCH4 (E3 Ubiquitin-protein Ligase MARCH4, Membrane-associated RING Finger Protein 4, Membrane-associated RING-CH Protein IV, MARCH-IV, RING Finger Protein 174, KIAA1399, RNF174)

Anti -MARCH4 (E3 Ubiquitin-protein Ligase MARCH4, Membrane-associated RING Finger Protein
4, Membrane-associated RING-CH Protein IV, MARCH-IV, RING Finger Protein 174, KIAA1399,
RNF174)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
RNF174 (MARCH4) is a multi-pass membrane protein mainly found in the membrane of Golgi apparatus. It is a complex enzyme with a RING-CH-type zinc finger. It acts as a ubiquitin-protein ligase mainly involved in third step of ubiquitin conjugation. The RINGv-type zinc finger domain is required for E3 ligase activity in which the E3 ubiquitin-protein ligase mediates ubiquitination of MHC-I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. It is mainly expressed in brain and placenta.
Catalog #M2867-61F
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 0.5-2ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to aa300-350 from human MARCH4 (KLH).
SpecificityRecognizes human MARCH4. Species sequence homology: Chimpanzee, chicken, canine, equine, mouse, opossum, rat and zebrafish.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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