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Anti -MERTK (Tyrosine-protein Kinase Mer, Proto-oncogene c-Mer, Receptor Tyrosine Kinase MerTK, MER)
Anti -MERTK (Tyrosine-protein Kinase Mer, Proto-oncogene c-Mer, Receptor Tyrosine Kinase
MerTK, MER)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B |
|
| MERTK is a novel transmembrane, receptor-like tyrosine kinase belonging to the MER/AXL/TYRO3 receptor kinase family with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and a tyrosine kinase domain. MERTK, a membrane protein, may have a functional role in filovirus infection, where it may act as a cell entry factor. MERTK is a GAS6 receptor, participating through binding to GAS6 in platelet function and platelet dependent thrombosis in vitro. Defects in MERTK have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). It is usually detected in normal peripheral blood monocytes, macrophages, bone marrow, and tissues of epithelial and reproductive origin. | | | Catalog # | M2995-02B | | Applications | Suitable for use in Western Blot. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-2ug/ml | | Optimal dilutions to be determined by the researcher. | | Positive Control | Spleen lysate | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.5mg/ml | | Form | Supplied as a liquid in PBS, 0.05% BSA, 0.05% sodium azide. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Synthetic peptide corresponding to aa50-100 of human MERTK. | | Specificity | Recognizes human MERTK. Species Crossreactivity | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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