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You are here:Home » Antibodies » Abs to Growth Factors, Cytokines » Anti -c-Met (Hepatocyte Growth Factor, Scatter Factor Receptor, HGF, SF, Hepatocyte Growth Factor Receptor Precursor, HGF Receptor, HGFR, HGF/SF Receptor, Met Proto-oncogene Tyrosine Kinase, Oncogene MET, Renal Cell Carcinoma Papillary 2 Gene, RCCP2, SF Recepto

Anti -c-Met (Hepatocyte Growth Factor, Scatter Factor Receptor, HGF, SF, Hepatocyte Growth
Factor Receptor Precursor, HGF Receptor, HGFR, HGF/SF Receptor, Met Proto-oncogene
Tyrosine Kinase, Oncogene MET, Renal Cell Carcinoma Papillary 2 Gene, RCCP2, SF Recepto

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH IC
Met is a receptor protein-tyrosine kinase (RPTK) for hepatocyte growth factor (HGF), which is a multifunctional cytokine controlling cell growth, morphogenesis, and motility. Met overexpression has been identified in a variety of human cancers (1). Met kinase domain possesses unique features that distinguish met from other members of the src family of protein tyrosine kinases. These results also demonstrate that the product of the activated met gene is a fusion protein and that the amino terminal end of this fusion protein exhibits homology to laminin B1 (2). Data suggest that RanBP9, functioning as an adaptor protein for the Met tyrosine kinase domain, can augment the HGF-Met signaling pathway and that RanBP9 overexpression may cause constitutive activation of the Ras signaling pathway (1). Hereditary papillary renal carcinoma (HPRC) is a recently recognized form of inherited kidney cancer Results suggest that missense mutations located in the MET proto-oncogene lead to constitutive activation of the Met protein and papillary renal carcinomas (3)
Catalog #M3007-03C
ApplicationsSuitable for use in Western Blot, Immunohistochemistry and Immunocytochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 1:2000
Immunohistochemistry: 1:100-1:250
Immunocytochemistry: 1:100-1:250
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9H469
HostRabbit
SourceHuman
ConcentrationNot Determined
FormSupplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 0.01% sodium azide, 0.05% BSA, 40% glycerol.
PuritySupernatant
ImmunogenSynthetic peptide corresponding to residues near the N-terminus of human Met.
SpecificityRecognizes human Met at ~190kD (full) and ~56 (cleaved).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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