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Anti -AMACR (Alpha-methylacyl-CoA Racemase, 2-methylacyl-CoA Racemase)
Anti -AMACR (Alpha-methylacyl-CoA Racemase, 2-methylacyl-CoA Racemase)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Ascites |
E B IH IF |
|
| Alpha-methyacyl-CoA racemase (AMCR), is an enzyme invloved in beta oxidation of branched chain fatty acids and bile salt intermediates, and has recently been identified as a neomarker for prostate cancer, where it is over expressed. Several different isoforms have been reported that are produced either by extensinve alternatve splicing of 5 exons or by use of alternate initiation codons. At least 2 different transcripts, each derived from the 5 exons, have been reported, AMCR I and AMCR II. AMCR I is the most abundant form and enclodes for a 382aa protein (42kD). The other isoform AMCR II exhibits significant homolgy to fumarate hydratase and encodes a 288aa protein (32kD). Several other variants of IA and IIA isoforms have been characterized recently. | | | Catalog # | M3390-01C | | Applications | Suitable for use in Immunofluorescence, Western Blot, ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunofluorescence: 1:200-1:1000 | | ELISA: 1:10,000 | | Western Blot: 1:500-1:2000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 1:200 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b | | Host | Mouse | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid. | | Purity | Ascites | | Immunogen | Recombinant corresponding to human AMACR-His fusion protein, expressed in E. coli strain BL21 (DE3) | | Specificity | Recognizes human AMACR. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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