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You are here:Home » Antibodies » Abs to Enzymes, Methyltransferase » Anti -MGMT (Methylated-DNA-protein-cysteine Methyltransferase, 6-O-methylguanine-DNA Methyltransferase, O-6-methylguanine-DNA-alkyltransferase)

Anti -MGMT (Methylated-DNA-protein-cysteine Methyltransferase, 6-O-methylguanine-DNA
Methyltransferase, O-6-methylguanine-DNA-alkyltransferase)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant IH
MGMT is a p53 related DNA repair protein that protects tissues against toxic and carcinogenic effects of alkylating agents and thus remains the first line defense against alkylation damage of DNA. This protein functions by a unique stoichiometric and suicidal reaction mechanism in which the alkyl groups bound to the O6-position of guanine are transferred to a cysteine in its active site, resulting in the direct restoration of the normal base and self-inactivation of MGMT protein. It is highly expressed in human cancers and is also a central determinant of tumor resistance to many clinically used anticancer alkylating agents. The gene for MGMT is mapped on 10q26 region of human chromosome.
Catalog #M3884-89C
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 1:25-1:50
Optimal dilutions to be determined by the researcher.
Positive ControlTonsil
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG1
Clone No11E280
HostMouse
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.05% sodium azide.
PuritySupernatant
ImmunogenRecombinant corresponding to human MGMT protein. Cellular Localization: Nuclear and cytoplasmic.
SpecificityRecognizes human MGMT.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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