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Anti -MGMT (Methylated-DNA-protein-cysteine Methyltransferase, 6-O-methylguanine-DNA Methyltransferase, O-6-methylguanine-DNA-alkyltransferase)
Anti -MGMT (Methylated-DNA-protein-cysteine Methyltransferase, 6-O-methylguanine-DNA
Methyltransferase, O-6-methylguanine-DNA-alkyltransferase)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
IH |
|
| MGMT is a p53 related DNA repair protein that protects tissues against toxic and carcinogenic effects of alkylating agents and thus remains the first line defense against alkylation damage of DNA. This protein functions by a unique stoichiometric and suicidal reaction mechanism in which the alkyl groups bound to the O6-position of guanine are transferred to a cysteine in its active site, resulting in the direct restoration of the normal base and self-inactivation of MGMT protein. It is highly expressed in human cancers and is also a central determinant of tumor resistance to many clinically used anticancer alkylating agents. The gene for MGMT is mapped on 10q26 region of human chromosome. | | | Catalog # | M3884-89C | | Applications | Suitable for use in Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (paraffin): 1:25-1:50 | | Optimal dilutions to be determined by the researcher. | | Positive Control | Tonsil | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG1 | | Clone No | 11E280 | | Host | Mouse | | Source | Human | | Concentration | Not determined. | | Form | Supplied as a liquid, 0.05% sodium azide. | | Purity | Supernatant | | Immunogen | Recombinant corresponding to human MGMT protein. Cellular Localization: Nuclear and cytoplasmic. | | Specificity | Recognizes human MGMT. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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