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You are here:Home » Antibodies » Abs to MHC » Anti -MHC Class 1

Anti -MHC Class 1

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E IH FC
Human MHC Class I (HLA-A, B & C) molecules are expressed on nearly all nucleated cells. MHC Class I molecules consist of heterodimers of a highly polymorphic transmembrane a chain and an invariant b chain. MHC Class I molecules bind to endogenously synthesized peptides of about 8-10 amino acids which are presented to CD8+ T cells. Recent evidence now indicates exogenously derived peptides are also presented by MHC Class I molecules.
Catalog #M3885-48D
Functional Application Antibody (whole molecule) is cytotoxic in the presence of complement (1).
ApplicationsSuitable for use in Flow Cytometry, ELISA and Immunohistochemistry. Other applications not tested.
Recommended Dilution Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No7H121
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in FBS, 50mM Sodium Phosphate pH 7.5, 100mM Potassium Chloride, 150mM NaCl, 0.5 mg/ml Gentamicin Sulfate.
PurityPurified by Protein A affinity chromatography.
ImmunogenHuman HSB-2 T cell line
SpecificityRecognizes a monomorphic Class I epitope on the a chain.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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