Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to MHC » Anti -MHC Class 1 Chain-related Gene A, B (MHC Class 1 Chain-related Gene A, MHC Class I Polypeptide-related Sequence A, MICA, MIC-A, MHC Class 1 Chain-related Gene B, MHC Class I Polypeptide-related Sequence B, MICB, MIC-B, PERB11.1, PERB11.2) (Biotin)

Anti -MHC Class 1 Chain-related Gene A, B (MHC Class 1 Chain-related Gene A, MHC Class I
Polypeptide-related Sequence A, MICA, MIC-A, MHC Class 1 Chain-related Gene B, MHC Class I
Polypeptide-related Sequence B, MICB, MIC-B, PERB11.1, PERB11.2) (Biotin)

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC
MICA and MICB are stress inducible antigens, which are closely related and appear functionally indistinguishable. MICA and MICB are ligands for NKG2D, an activating receptor on most natural killer (NK) cells, CD8 T cells and gamma delta T cells.
MICA is principally expressed on intestinal epithelium, and several epithelial tumours. Expression may be induced to high surface levels by heat shock, oxidative stress, and virus infection.
Catalog #M3886-75Y2
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionsFlow Cytometry: Neat-1:10; 10ul labels 10e6 cells in 100ul
Immunohistochemistry: Frozen sections. Membrane permeabilization is required.
Optimal dilutions to be determined by the researcher.
HybridomaP3 myeloma cells with spleen cells from RBF/DnJ mice.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No10F158
HostMouse
SourceHuman
Concentration~0.1mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 1% BSA, 0.09% sodium azide. Labeled with Biotin.
PurityPurified by Protein G affinity chromatography.
ImmunogenMICA transfected C1R cells
SpecificityRecognizes human nonclassical MHC class I chain A (MICA) and nonclassical MHC class I chain MICB (MICB). Reported to inhibit the cytotoxicity of NK cells stimulated by IFN alpha-treated dendritic cells.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links