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You are here:Home » Antibodies » Abs to MHC » Anti -MHC Class 2 Ia (HLA DR)

Anti -MHC Class 2 Ia (HLA DR)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH FC
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of an a chain (36 kDa) and a beta chain (27kD). It is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.
Catalog #M3887-30
ApplicationsSuitable for use in Flow Cytometry and Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Frozen and bouin or paraffin): 2-4ug/ml for 30 minutes at RT.
Optimal dilution to be determined by researcher.
Positive ControlTonsil/lymph node
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No0.N.422
HostMouse
SourceHuman
Concentration~0.2mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.09% sodium azide.
PurityPurified by Protein A affinity chromatography.
ImmunogenActivated human peripheral blood mononuclear cells. Cellular Localization
SpecificityRecognizes a human non-polymorphic antigen of the HLA-DR, Ia region. Reacts with B-cells of the germinal centers and mantle zones. It also recognizes monocytes, macrophages and interdigitating histiocytes.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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