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You are here:Home » Antibodies » Abs to Enzymes, Protease (Proteinase, Peptidase) » Anti -MIPEP (MIP, HMIP, Mitochondrial Intermediate Peptidase, MIPEP)

Anti -MIPEP (MIP, HMIP, Mitochondrial Intermediate Peptidase, MIPEP)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum E
MIPEP contains a typical mitochondrial leader peptide with 54% homology to mitochondrial intermediate peptidase of Saccharomyces cerevisiae YMIP. MIPEP is primarily involved in the maturation of oxidative phosphorylation (OXPHOS) related proteins. The protein is differentially expressed in human tissues, with the highest levels of expression in the heart, skeletal muscle, and pancreas, the organ systems frequently affected in OXPHOS disorders. The potential involvement of MIPEP in the pathophysiology of nuclear-driven OXPHOS disorders has been studied. The protein also contributes to the functional effects of frataxin deficiency and the clinical manifestations of a neurodegenerative disease, Friedreich's ataxia (FRDA). MIPEP locus is assigned to 13q12.
Catalog #M3949-55B
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationNot determined.
FormSupplied as a liquid, 0.025% sodium azide, 50% glycerol.
PuritySerum
ImmunogenSynthetic peptide corresponding to aa79-96 (IAQEKALRKTELLVDRAC) of human MIPEP.
SpecificityRecognizes human MIPEP. Species sequence homology: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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