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You are here:Home » Antibodies » Abs to Matrix Metalloproteinases » Anti -MMP-14b, Hinge (Matrix Metallopeptidase 14b, Membrane-type Matrix Metalloproteinase 1 beta)

Anti -MMP-14b, Hinge (Matrix Metallopeptidase 14b, Membrane-type Matrix Metalloproteinase
1 beta)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E B IH
MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family, ten exist in soluble form, whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2- MMP, and MT3-MMP, also known as MMP-14, MMP-15, and MMP-16, respectively, contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8aa insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2, forming a trimer. MT1- MMP also has direct activity against a number of ECM proteins, including gelatin, fibronectin, vitronectin, fibrillar collagens, and aggrecan. Studies on the zebrafish model have illuminated the function of MMP-14 on the remodeling, fin regeneration, and gastrulation.
Catalog #M4145-01W
ApplicationsSuitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested.
Recommended DilutionELISA: 1:5000-1:20,000
Western Blot: 1:500-1:1000
Immunohistochemistry: 1:50-1:200
Optimal dilutions to be determined by the researcher.
Control Peptide M4145-01W1
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceZebrafish
ConcentrationNot determined
FormSupplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the hinge region of zebrafish MMP-14-beta.
SpecificityRecognizes zebrafish MMP-14-beta.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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