Anti -MMP-14b, Hinge (Matrix Metallopeptidase 14b, Membrane-type Matrix Metalloproteinase
1 beta)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B IH |
|
| MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family, ten exist in soluble form, whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2- MMP, and MT3-MMP, also known as MMP-14, MMP-15, and MMP-16, respectively, contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8aa insert in their catalytic domain. MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT1-MMP gets activated through the membrane plasmin cascade. It binds to TIMP-2 first and then to MMP-2, forming a trimer. MT1- MMP also has direct activity against a number of ECM proteins, including gelatin, fibronectin, vitronectin, fibrillar collagens, and aggrecan. Studies on the zebrafish model have illuminated the function of MMP-14 on the remodeling, fin regeneration, and gastrulation. | | | Catalog # | M4145-01W | | Applications | Suitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | ELISA: 1:5000-1:20,000 | | Western Blot: 1:500-1:1000 | | Immunohistochemistry: 1:50-1:200 | | Optimal dilutions to be determined by the researcher. | | Control Peptide | M4145-01W1 | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Zebrafish | | Concentration | As reported | | Form | Supplied as a liquid in 40mM MOPS, pH 7.5, 0.1% BSA, 0.05% sodium azide, 50% glycerol. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to the hinge region of zebrafish MMP-14-beta. | | Specificity | Recognizes zebrafish MMP-14-beta. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
External Links
|
