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Specifications

Clone Host Grade Applications Monoclonal Mouse Affinity Purified E B IP IH

Moesin, a member of the talin-4 superfamily, is localized just beneath the plasma membrane and is believed to be involved in the mediation of interactions between cytoskeletal and membrane proteins. The ERM proteins, ezrin, radixin and moesin, are involved in a variety of cellular functions, such as cell adhesion, migration and the organization of cell surface structures. They are highly homologous, both in protein sequence and in functional activity with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.
Catalog #	M4300-01
Applications	Suitable for use in ELISA, Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested.
Recommended Dilution	Western Blot: 1:1000
	Immunohistochemistry: Frozen
	Optimal working dilutions to be determined by researcher.
Recommended Positive Control Tissue	Human Tonsil
Recommended Secondary Antibody	I1904-65W: IgG, F(ab’)2 (HRP) Pab Rb x Mo
	I1904-14C: IgG, Fc (HRP) Pab Gt x Mo
Hybridoma	AG8 myeloma cells with spleen cells from BALB/c mice.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Monoclonal
Isotype	IgG1
Clone No	3H2729
Host	Mouse
Concentration	~1mg/ml
Form	Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
Purity	Purified by Protein G affinity chromatography.
Immunogen	Purified moesin
Specificity	Recognizes the 78kD human moesin protein. Also shows some crossreactivity with the related protein radixin, but not with ezrin.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.