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You are here:Home » Biochemicals » Biochem-Antibiotics » Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B)

Monactin (5-demethyl-5-ethylnonactin, Antibiotic AKD 1B)


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Monactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. Unlike nonactin, monactin has not previously been available for intensive investigation. Early literature reported that the related dinactin is a monovalent cation ionophore with high selectivity for ammonium and potassium. Monactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-gamma.
Catalog #M4431
Purity >95% by HPLC
Solubility Soluble in ethyl acetate or DMSO, moderately in soluble ethanol or methanol.
Related to Dinactin, Trinactin
CAS Number7182-54-9
Molecular FormulaC41H66O12
Molecular Weight750.96
SourceStreptomyces sp.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate names5-demethyl-5-ethylnonactin, Antibiotic AKD 1B

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