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Abs to Monocarboxylate Transporter
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Anti -Monocarboxylate Transporter 5 (MCT5, MOT5)
Anti -Monocarboxylate Transporter 5 (MCT5, MOT5)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
E B |
|
| Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner. | | | Catalog # | M4470-40 | | MCT5/SLC16A4 (mouse 468-aa, human 487-aa, chromosome 1p13.1) shares 25% sequence homology with MCT1, but it has much shorter C-terminus than other MCTs. MCT5 has an Alu insertion even in the 3'-UTR and a truncated C-terminus. High expression of MCT5 has been observed in placenta. According to new nomenclature, the old MCT4 has now been reclassified as MCT5. | | Applications | Suitable for use in ELISA and Western Blot. Other applications not tested. | | Recommended Dilutions | ELISA: 1:10,000-1:100,000 using 50–100ng control peptide per well. See Catalog #M4470-40B. | | Western Blot: 1-5ug/ml using ECL. | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~1mg/ml (after reconstitution) | | Form | Supplied as a lyophilized powder from PBS, 0.1% BSA. Reconstitute with 100ul sterile PBS. | | Purity | Purified by immunoaffinity chromatography. | | Immunogen | Synthetic peptide corresponding to a 19aa sequence within the cytoplasmic domain #4, near the C-terminus of human MCT5 conjugated to KLH. Species Sequence Homology: mouse MCT5, 65%. | | Specificity | Recognizes human Monocarboxylate Transporter 5 (MCT5/MOT5). Reactivity with other members of the MCT family is unlikely because the immunogen shows no significant sequence homology with other MCTs. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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