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You are here:Home » Antibodies » Abs to Monocarboxylate Transporter » Anti -Monocarboxylate Transporter 7 (MCT7)

Anti -Monocarboxylate Transporter 7 (MCT7)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum
Monocarboxylate such as lactate and pyruvate play an important role in cellular metabolism. Lactic acid is produced as the end product of glycolysis. Some tissues, such as white skeletal muscle and, red blood cells, use this pathway to generate most of their ATP under normal physiological conditions. All tissues become dependent on this pathway during abnormal conditions such as hypoxia and ischaemia. Lactic acid, produced during normal glycolysis, must be transported out of cells to sustain maintain high rate of glycolysis. Failure to export lactic acid leads to accumulation of cellular lactic acid followed by an increase in pH and inhibition of glycolysis. Some tissues, such as brain, heart, and red skeletal muscle, readily oxidize lactic acid, and must import lactic acid into the cells. Lactic acid transport is mediated by a group of proton-linked membrane transporters called monocarboxylic acid transporters (MCTs). At least 9 MCT-related proteins (MCT1-9) have been identified in mammals that are expressed in a tissue specific manner.
Catalog #M4470-60A
MCT7/MOT7/SLC16A6 (mouse, 523-aa; human 423-aa, chromosome 17q25.1) is a new member of MCT family. According to new nomenclature, the old MCT6 has now been reclassified as MCT7. This antibody has previously been listed as MCT62-S. Please consult the main MCT page for details on the new nomenclature.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid, neat serum, 40% glycerol.
PuritySerum
ImmunogenA 20-aa peptide sequence within the Cytoplasmic, C-terminus of human MCT7 (1) was synthesized, coupled to KLH
SpecificityRecognizes human Monocarboxylate Transporter 7 (MCT7).
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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