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Anti -MLP (MARCKS-related Protein, MARCKS-like Protein 1, Macrophage Myristoylated Alanine-rich C Kinase Substrate, Mac-MARCKS, MacMARCKS, MARCKSL1, MRP)
Anti -MLP (MARCKS-related Protein, MARCKS-like Protein 1, Macrophage Myristoylated
Alanine-rich C Kinase Substrate, Mac-MARCKS, MacMARCKS, MARCKSL1, MRP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Affinity Purified |
E B IH |
|
| Protein kinase C is a key enzyme of intracellular signal transduction. The myristoylated, alanine-rich protein MARCKS, is a widely expressed, prominent substrate for protein kinase C.The severe neural tube defects (NTD) including exencephaly, spina bifida, and tail flexion anomaly in approximately 60% of the homozygous mutants and in approximately 10% of heterozygous animals. The homozygous mutants without exencephaly survived despite brain abnormalities, which appear to occur secondarily to the NTD.It has been suggested that mutations in Mrp result in isolated NTD and therefore may provide an animal model for common human NTD. | | | Catalog # | M4688-19B | | Applications | Suitable for use in ELISA, Western Blot and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:500-1:1000 | | Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2b,k | | Clone No | 8C8 | | Host | Mouse | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2. | | Purity | Purified by Protein A affinity chromatography. | | Immunogen | Recombinant corresponding to aa107-196 from human MARCKSL1 with GST tag. MW of the GST tag alone is 26kD. | | Specificity | Recognizes human MARCKSL1. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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