Login

Forgot your password?
New User?
Remember me
banner banner

You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -MRP2 (Multidrug Resistance Associated Protein 2, ABC30, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 2, ATP Binding Cassette Sub-family C Member 2, ABCC2, Canalicular Multidrug Resistance Protein, cMRP, Canalicular Multispecific Organic Anion Trans

Anti -MRP2 (Multidrug Resistance Associated Protein 2, ABC30, ATP-binding Cassette
Sub-family C (CFTR/MRP) Member 2, ATP Binding Cassette Sub-family C Member 2, ABCC2,
Canalicular Multidrug Resistance Protein, cMRP, Canalicular Multispecific Organic Anion
Trans

Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant B IH IF
The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N-terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the asolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression.
Catalog #M4688-20
ApplicationsSuitable for use in Immunofluorescence, Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50%glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No8L798
HostMouse
SourceHuman
ConcentrationNot determined
FormAs reported
PurityTissue culture supernatant
ImmunogenRaised against amino acids of 215-310 of human MRP 2.
SpecificitySpecies Crossreactivity: Does not crossreact with MDR1, MRP1, MRP3 or MRP5.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


External Links