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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -MRP5 (Multidrug Resistance-associated Protein 5, ABC33, ATP-binding Cassette Sub-family C (CFTR/MRP) Member 5, ATP Binding Cassette Sub-family C Member 5, ABCC5, Canalicular Multispecific Organic Anion Transporter C, DKFZp686C1782, EST277145, Multispecifi

Anti -MRP5 (Multidrug Resistance-associated Protein 5, ABC33, ATP-binding Cassette
Sub-family C (CFTR/MRP) Member 5, ATP Binding Cassette Sub-family C Member 5, ABCC5,
Canalicular Multispecific Organic Anion Transporter C, DKFZp686C1782, EST277145,
Multispecifi

Pricing

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Specifications

Clone Host Grade Applications
Polyclonal Goat Serum E B
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Catalog #M4688-27A
ApplicationsSuitable for use in ELISA and Western Blot. Other applications not tested.
Recommended DilutionELISA: 1:32,000
Western Blot: 0.5-1.5ug/ml ~150kD band observed in Human Brain (Frnotal Cortex) and Mouse Brain lysates (calculated MW of 161kD according to NP_005679.2)
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 3 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypePolyclonal
IsotypeIgG
HostGoat
SourceHuman
ConcentrationAs reported
FormSupplied as a liquid in Tris-saline, pH 7.3. 0.5% BSA, 0.02% sodium azide.
PuritySerum
ImmunogenSynthetic peptide corresponding to KDIDIGKEYIIP-C, from the N Terminus of human ABCC5 (NP_005679.2; NP_001018881.1)
SpecificityRecognizes human ABCC5. Species sequence homology: mouse and bovine.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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