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You are here:Home » Antibodies » Abs to Multi Drug Resistance (MDR) » Anti -MRP5 (Multidrug Resistance-associated Protein 5, ABC33, ATP-binding Cassette Sub-family C Member 5, ABCC5, DKFZp686C1782, EST277145, Multi-specific Organic Anion Transporter C, MOATC, MOAT-C, pABC11, SMRP)

Anti -MRP5 (Multidrug Resistance-associated Protein 5, ABC33, ATP-binding Cassette
Sub-family C Member 5, ABCC5, DKFZp686C1782, EST277145, Multi-specific Organic Anion
Transporter C, MOATC, MOAT-C, pABC11, SMRP)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Supernatant B IH IC FC
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.
Catalog #M4688-27C
ApplicationsSuitable for use in Immunocytochemistry, Immunohistochemistry, Flow Cytometry and Western Blot. Other applications not tested.
Recommended DilutionImmunocytochemistry (acetone fixed): 1:20-50
Immunohistochemistry (acetone fixed frozen): 1:20
Western Blot: 1:20-50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone NoM5II-54
HostRat
Concentration~250ug immunoglobulin/ml (by ELISA).
FormSupplied as a liquid in 0.7% BSA, 0.1% sodium azide.
PuritySupernatant
ImmunogenBacterial fusion protein of MRP5, containing aa722-910 of the protein.
SpecificityRecognizes an internal epitope of MRP5, a 190-200kD transmembrane protein that is closely related to the multidrug resistance protein MRP. Does not cross-react with the human MDR1, MRP1, MRP2 or MRP3 gene products.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesATP-binding Cassette, Sub-family C (CFTR/MRP), Member 5


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