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You are here:Home » Biochemicals » Biochem-Antibiotics » MS-275 (Entinostat, SNDX-275)

MS-275 (Entinostat, SNDX-275)


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MS-275 is a synthetic benzamide derivative that inhibited partially purified human histone deacetylase (HDA) with an IC50 of 2uM and induced hyperacetylation of nuclear histones in tumor cell lines. MS-275 inhibited the proliferation of various human tumor cell lines such as A2780, Calu-3, HL-60, and K562 (IC50 values were 0.0415uM, 0.195uM, 0.212uM, and 0.589uM, respectively). MS-275 also inhibited the growth of human tumor xenografts in nude mouse.
Catalog #M4693-15A
SolubilitySoluble in DMSO at 25mg/ml with slight warming; very poorly soluble in ethanol and water; maximum solubility in plain water is estimated to be about 10-20uM. buffers, serum, or other additives may increase or decrease the aqueous solubility.
Melting Point216-218ºC
Elemental AnaylsisCalculated:
Storage and StabilityMay be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number209783-80-2
Molecular FormulaC21H20N4O3
Molecular Weight376.41
FormSupplied as a white to off-white powder.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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