Pricing

  For pricing information, USA customers sign in.
  Outside USA? Please contact your distributor for pricing.

Specifications

MS-275 is a synthetic benzamide derivative that inhibited partially purified human histone deacetylase (HDA) with an IC50 of 2uM and induced hyperacetylation of nuclear histones in tumor cell lines. MS-275 inhibited the proliferation of various human tumor cell lines such as A2780, Calu-3, HL-60, and K562 (IC50 values were 0.0415uM, 0.195uM, 0.212uM, and 0.589uM, respectively). MS-275 also inhibited the growth of human tumor xenografts in nude mouse.
Catalog #	M4693-15A
Solubility	Soluble in DMSO at 25mg/ml with slight warming; very poorly soluble in ethanol and water; maximum solubility in plain water is estimated to be about 10-20uM. buffers, serum, or other additives may increase or decrease the aqueous solubility.
Melting Point	216-218ºC
Elemental Anaylsis	Calculated:
	C=67.01%
	H=5.36%
	N=14.88%
Storage and Stability	May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 12 months. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
CAS Number	209783-80-2
Molecular Formula	C21H20N4O3
Molecular Weight	376.41
Purity	~99%
Form	Supplied as a white to off-white powder.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.