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You are here:Home » Antibodies » Abs to Mucin » Anti -Mucin 1 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Sequence, H23 An

Anti -Mucin 1 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3,
Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane
Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Sequence, H23 An

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E IH
MUC1 is a large cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells and some hematopoietic cell lineages. It is expressed on most secretory epithelium, including mammary gland and some hematopoietic cells. It is expressed abundantly in lactating mammary glands and overexpressed abundantly in >90% breast carcinomas and metastases. Transgenic MUC1 has been shown to associate with all four cebB receptors and localize with erbB1 (EGFR) in lactating glands. The MUC1 gene contains seven exons and produces several different alternatively spliced variants. The major expressed form of MUC1 uses all seven exons and is a type 1 transmembrane protein with a large extracellular tandem repeat domain. The tandem repeat domain is highly O glycosylated and alterations in glycosylation have been shown in epithelial cancer cells.
Catalog #M4700-05X
ApplicationsSuitable for use in ELISA, Dot Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionsELISA: 1:10,000
Immunohistochemistry (Paraffin): 1:200
Dot Blot: 1:10,000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, stabilizing protein, cryogenic reagents, sodium azide.
PurityPurified by affinity chromatography.
ImmunogenSynthetic peptide representing a 20 amino acid repeat sequence (VTS APD TRP APG STA PPA HG), from human mucin 1, conjugated to KLH. Cellular Localization: Cell Membrane and Secreted
SpecificityRecognizes underglycosylated human mucin 1.
Species CrossreactivityMouse and rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Alternate namesCD227 Antigen


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