Anti -Mucin 1, isoform 7 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen
DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement
Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Seque
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
B IP IH FC |
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| Mucins are high molecular weight glycoproteins that provide a protective layer on epithelial surfaces and are involved in cell-cell interactions, signaling, and metastasis. MUC1 consists of an extracellular subunit and a membrane-associated subunit (1). The two moieties are produced from a single precursor polypeptide by an early proteolytic cleavage event but remain associated throughout intracellular processing and transport to the cell surface. It has been shown that MUC1 expression inhibits erbB1 (regulators of cell survival and growth) degradation and also E-cadherin (2). Isoform 7 of MUC1 behaves as a receptor and binds the secreted isoform 5. The binding induces the phosphorylation of the isoform 7, alters cellular morphology and initiates cell signaling (3). | | | Catalog # | M4700-14A | | Applications | Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation, Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 1:1000 | | Immunohistochemistry: 1:100-1:250 | | Flow cytometry: 1:30 | | Immunoprecipitation: 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9E387 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% Glycerol, 0.01% sodium azide and 0.05% BSA. | | Purity | Supernatant | | Immunogen | A synthetic peptide corresponding to residues near the N-terminus of human MUC1. | | Specificity | Recognizes human MUC1. Species crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. | | Alternate names | MUC-1, Polymorphic epithelial mucin, PEM, PEMT, Episialin, Tumor-associated mucin, Carcinoma-associated mucin, Tumor-associated epithelial membrane antigen, EMA, H23AG, Peanut-reactive urinary mucin, PUM, Breast carcinoma-associated antigen DF3, CD227 ant |
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Download Specifications for Anti -Mucin 1, isoform 7 (MUC1 Glycoprotein, MUC-1, Breast Carcinoma Associated Antigen DF3, CA 15-3, Carcinoma Associated Mucin, CD227, DF3, EMA, Episialin, Epithelial Basement Membrane Antigen, Epithelial Membrane Antigen, Epithelial Mucin Tandem Repeat Seque |
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