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You are here:Home » Antibodies » Abs to Mucin » Anti -Mucin 5AC (MUC5AC Glycoprotein, Gastric Mucin M1) (BSA & Azide Free)

Anti -Mucin 5AC (MUC5AC Glycoprotein, Gastric Mucin M1) (BSA & Azide Free)


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Clone Host Grade Applications
Monoclonal Mouse Affinity Purified IH
Mucins are high molecular eight glycoproteins with 80%carbohydrate contents and the remaining 20% is constituted by protein core. Gastric mucin M1 antigens are detected/found in columnar mucus cells of surface gastric epithelium and in goblet cells of the fetal and precancerous colon but not in those of normal colon. Evidence from the literature suggestes that they are associated with the peptide core of mucins Resurgence of gastric mucin reactivity during colonic carcinogenesis is suggested to be due to either re-expression of the peptide core of gastric (or fetal colonic) mucins in the adult colon or due to changes in the glycosylation pattern of mucin which expose the hidden M1 antigens.
Catalog #M4701-06X
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionsImmunohistochemistry (Formalin/paraffin): 1-2ug/ml for 30 minutes at RT. No special pretreatment is required for immunohistochemical staining of formalin-fixed tissues.
Optimal dilutions to be determined by the researcher.
EpitopeThe epitope is destroyed by b-mercaptoethanol and proteases treatment. It is not destroyed by periodate treatment.
Positive Control Stomach
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
Clone No0.N.458
FormSupplied as a liquid in PBS, pH 7.4. No stabilizing proteins and no preservative added. Also available with BSA and azide. See M4701-06.
PurityPurified by Protein G affinity chromatography.
ImmunogenM1 mucin preparation from the fluid of an ovarian mucinous cyst belonging to an O Le(a-b-) patient. Cellular Localization: Cytoplasmic and cell surface
SpecificityRecognizes the peptide core of gastric mucin M1 (>1000kD) (recently identified as Mucin 5AC).
Species CrossreactivityHuman, monkey, rabbit, feline, mouse, rat, chicken and bovine. Does not crossreact with porcine or hedgehog.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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