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You are here:Home » Antibodies » Abs to Mucin » Anti -Mucin 13 (MUC13, MUC-13, Down-regulated in Colon Cancer 1, DRCC1, FLJ20063, Mucin 13 Cell Surface Associated, PRO20221, RECC, UNQ6194)

Anti -Mucin 13 (MUC13, MUC-13, Down-regulated in Colon Cancer 1, DRCC1, FLJ20063, Mucin 13
Cell Surface Associated, PRO20221, RECC, UNQ6194)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified E
Mucin 13 is a 512aa hemopoietic transmembrane mucin belonging to a family of secreted and cell surface glycoproteins and may play a role in cell signaling. It contains a serine/threonine-rich mucin repeat domain predicted to be heavily O-glycosylated, three cysteine-rich EGF-like domains, a SEA domain and also has sites for N-glycosylation and phosphorylation. Activation of NF-kappa-B signaling pathway by the inflammatory cytokines TNF-alpha and TGF-beta leads to upregulation of Mucin 13. It is a homodimer of beta subunits and is highly expressed in epithelial tissues, gastrointestinal and respiratory tracts, kidney, small intestine, appendix and stomach. RT-PCR and immunoblot analysis supports the up regulation of Mucin 13 in gastric cancers and is usually present on the apical side of tubular glands in intestinal-type cancers and in the cytoplasm in diffuse cancers.
Catalog #M4701-85
ApplicationsSuitable for use in ELISA. Other applications not tested.
Recommended DilutionPeptide ELISA: 1:100-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.2% gelatin, 0.05% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa44-58, DTTETNFPETASTTA of human MUC13.
SpecificityRecognizes human Mucin 13.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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