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You are here:Home » Antibodies » Abs to RNA Processing » Anti -Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428)

Anti -Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL
Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174,
EXP, EXP35, EXP40, EXP42, KIAA0428)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified B IF
Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.
Catalog #M9426-01A
Cellular Localization Nuclear
ApplicationsSuitable for use in Immunofluorescence and Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile 40-50%glycerol, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1,k
Clone No8L845
HostMouse
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in Tris-glycine, 150mM sodium chloride, pH 7.2.
PurityPurified by Protein G affinity chromatography.
ImmunogenFusion muscleblind-like1p/p60 human protein. Epitope: Amino acids 116-182.
SpecificityThis antibody is specific for MBNL 1p protein. Species Crossreactivity: This antibody works in human samples
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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