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You are here:Home » Antibodies » Abs to RNA Processing » Anti -Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174, EXP, EXP35, EXP40, EXP42, KIAA0428)

Anti -Muscleblind-like 1 (MBNL1, EXP35, EXP40, EXP42, Muscleblind-like, MBNL, MBNL
Protein, Muscleblind 41kD Isoform, Triplet Expansion RNA Binding Protein, DKFZp686P06174,
EXP, EXP35, EXP40, EXP42, KIAA0428)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B
MBNL1 protein is a 343 amino acid peptide with an estimated molecular weight of 36.5kD. It binds to CUG triplet repeat expansion dsRNA.
Catalog #M9426-01D
Several important human diseases are associated with expansion of polynucleotide sequences, in most cases trinucleotide repeats. Myotonic dystrophy (DM1) is one of these diseases, and is associated with increases in the number of CTG repeats in the 3' UTR of the gene encoding myotonin (a.k.a. DM Kinase, DMK or myotonin-Protein Kinase), a ser/thr kinase expressed specifically in muscle. Mammalian genomes contain three muscleblind-like proteins, generally referred to as MBNL1, MBNL2 and MBNL3, and all three were found to associate with long double stranded CUG RNA repeats, thus, being triplet repeat expansion dsRNA-binding proteins.
ApplicationsSuitable for use in ELISA, Western Blot. Other applications not tested.
Recommended DilutionOptimal dilutions to be determined by the researcher.
Storage and StabilityLyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile 40-50% glycerol, ddH2O. Reconstituted product is stable for 12 months at -20°C. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG
Clone No9G382
HostMouse
SourceHuman
ConcentrationAs reported
FormSupplied as a lyophilized powder from PBS, pH 7.2. Reconstitute with 100ul sterile ddH2O.
PurityPurified by affinity chromatography.
ImmunogenRecombinant human MBNL1 protein (1-343), with a GST tag.
SpecificityRecognizes human MBNL1. Species crossreactivity: mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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