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You are here:Home » Antibodies » Abs to RNA Binding Proteins » Anti -Musashi-2 RNA Binding Protein (NT) (Musashi 2, Musashi2, Msi2, Msi-2, Musashi Homolog 2, RNA Binding Protein Musashi Homolog 2)

Anti -Musashi-2 RNA Binding Protein (NT) (Musashi 2, Musashi2, Msi2, Msi-2, Musashi
Homolog 2, RNA Binding Protein Musashi Homolog 2)

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Specifications

Clone Host Grade Applications
Monoclonal Rabbit Supernatant B IH FC
Musahi2 (Msi2) is a member of Musashi family of evolutionarily conserved RNA-binding proteins. In mammals, Musahi1 and 2 shares similar primary structure, RNA binding specificity, and expression profile during CNS development. Highly co-expressed with Musahi1 in neural precursor cells, Musahi2 has been linked to proliferation and maintenance of stem cells in central nervous system. With two conserved tandem RNA recognition motifs, Musashi2 binds to target mRNAs and regulates RNA expression at translation level (1). Chromosomal aberrations involving Mushahi2 might play a role in disease progression for chronic myeloid leukemia (2).
Catalog #M9515-02
In mammals, the Musashi family is important for cell fate determination, playing roles in maintenance of the stem-cell state, differentiation and tumorigenesis. MSI2 or Musashi2 is a member of RNA-binding proteins that appear to play central roles in post transcriptional gene regulation. The MSI2 gene encodes a protein containing two conserved tandem RNA recognition motifs. MSI2 may have a unique role that is required for the generation and/or maintenance of specific neuronal lineages.
ApplicationsSuitable for use in Flow Cytometry, Immunohistochemistry, and Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000-1:2000
Immunohistochemistry: 1:100-1:250
Flow Cytometry: 1:30
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Manufactured incorporating RabMAb® technology under Epitomics US patents, No 5,675,063 and 7,429,487, owned by Abcam.
Clone TypeMonoclonal
IsotypeIgG
Clone No9E389
HostRabbit
SourceHuman
ConcentrationNot determined
FormSupplied as a liquid in 50 mM Tris-Glycine, pH 7.4, 0.15 M sodium chloride, 40% glycerol, 0.01% sodium azide and 0.05% BSA.
PuritySupernatant
ImmunogenA synthetic peptide corresponding to N-terminus of human Musashi2.
SpecificityRecognizes human Musashi 2. Species crossreactivity; mouse and rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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