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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Muscarinic Receptor M1, aa451-460 (Cholinergic Muscarinic Receptor M1, Chrm1)

Anti -Muscarinic Receptor M1, aa451-460 (Cholinergic Muscarinic Receptor M1, Chrm1)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Purified E B IH
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.
Catalog #M9520-03
ApplicationsSuitable for use in Western Blot, ELISA and Immunohistochemistry. Other applications have been tested.
Recommended DilutionWestern Blot: 20ug/ml using whole rat brain homogenate
Immunohistochemistry: 5ug/ml using ABC techniques has been found to stain PLP fixed rat brain sections known to express the muscarinic M1 receptor.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 
Clone TypePolyclonal
IsotypeIgG
HostRabbit
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.2, 10mg/ml BSA.
PurityPurified by precipitation, dialysis and chromatography.
ImmunogenPeptide analogue of the carboxyl terminal of the M1 receptor covalently attached onto a carrier protein.
SpecificityRecognizes human and rat Muscarinic Receptor M1.
CrossreactivityM1 (aa451-460)
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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