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You are here:Home » Antibodies » Abs to Receptors, Cholinergic » Anti -Muscarinic Acetylcholine Receptor M2 (Cholinergic Receptor Muscarinic 2, CHRM2, FLJ43243, HM2, MGC120006, MGC120007)

Anti -Muscarinic Acetylcholine Receptor M2 (Cholinergic Receptor Muscarinic 2, CHRM2,
FLJ43243, HM2, MGC120006, MGC120007)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified IH
Muscarinic cholinergic receptor 2, an Acetylcholine Receptor, has been suggested to function as a presynaptic autoreceptor that inhibits acetylcholine release. The M2 receptor has also been suggested to mediate smooth muscle contractility. Alzheimer's disease (AD) involves selective loss of M2 subtype receptors in cortical and hippocampal regions of the Human brain. Increase in M2 receptor heterozygosity has been associated with depression in women. The M2 receptor has been reported to be expressed in various regions of the brain including the cerebellum, cerebral cortex, hippocampus, medulla, striatum, and thalamus, and in lung and prostate.
Catalog #M9520-11G
ApplicationsSuitable for use in Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (paraffin): 6-15ug/ml
Optimal dilutions to be determined by the researcher.
Positive ControlHuman brain, neurons and glia
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~1mg/ml
FormSupplied as a liquid in PBS, pH 7.7, 0.01% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenSynthetic peptide corresponding to the 3rd cytoplasmic domain of human mAChR M2.
SpecificityRecognizes human mAChR M2. Species Crossreactivity: rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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