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Mycophenolic Acid (Melbex, Lilly 68618, NSC 129185)
Mycophenolic Acid (Melbex, Lilly 68618, NSC 129185)
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| Mycophenolic acid is a common Penicillium metabolite first reported in the 1930s as a possible mycotoxin. Re-investigation has shown mycophenolic acid to display a broad range of pharmacological activities including antitumor, antiviral, antifungal and antiprotozoan activities. However, it was the discovery that mycophenolic acid was a potent immunosuppressant, useful to prevent kidney transplant rejection, that led to its commercial development and that of related semi-synthetics as pharmaceuticals. Mycophenolic acid acts by inihibition of inosine monophosphate dehydrogenase, controlling the rate of de novo purine synthesis in the proliferation of B and T lymphocytes. | | | Catalog # | M9580-16E | | Source | Penicillium sp. MST-FP1988 | | Apperance | White solid | | Solubility | Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | 24280-93-1 | | Molecular Formula | C17H20O6 | | Molecular Weight | 320.3 | | Source | Penicillium sp. MST-FP1988 | | Purity | ~99% | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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