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Anti -MYC, Phosphorylated (Thr58/Ser62) (Myc Proto-oncogene Protein, Class E Basic Helix-loop-helix Protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription Factor p64, BHLHE39)
Anti -MYC, Phosphorylated (Thr58/Ser62) (Myc Proto-oncogene Protein, Class E Basic
Helix-loop-helix Protein 39, bHLHe39, Proto-oncogene c-Myc, Transcription Factor p64,
BHLHE39)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Polyclonal |
Rabbit |
Affinity Purified |
B IP IH |
|
| The transcription factor c-Myc is a short-lived nuclear phosphoprotein involved in cell proliferation, differentiation and cancer regulation. c-Myc binds to DNA and activates transcription as a heterodimeric complex with Max. c-Myc is phosphorylated in vitro by MAP Kinase at Ser62 and in vivo c-Myc is phosphorylated at both Thr58 and Ser62. Mutation of The58 and Ser62 to Ala inhibits the ability of c-Myc to activate transcription, suggesting that phosphorylation regulates the ability of c-Myc to stimulate transcription. c-Myc appears to regulate multiple aspects of growth control: it promotes cell proliferation in the presence of cdk inhibitors and induces apoptosis with overexpression in serum deprived cells. | | | Catalog # | M9600-96R | | Applications | Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Western Blot: 0.5-4ug/ml | | Immunoprecipitation: 2-4ug/ml | | Immunohistochemistry: 10-20ug/ml | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Polyclonal | | Isotype | IgG | | Host | Rabbit | | Source | Human | | Concentration | ~0.1mg/ml | | Form | Supplied as a liquid in PBS, pH 7.2, 1% BSA, 0.02% thimerosal, 50% glycerol. | | Purity | Purified by affinity chromatography. | | Immunogen | Synthetic phosphopeptide corresponding to Thr58/Ser62 from human c-Myc. | | Specificity | Recognizes human c-myc. Species Crossreactivity: mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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