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Specifications

Clone Host Grade Applications Polyclonal Rabbit Affinity Purified IH IF

Mycobacterium tuberculosis is the etiologic agent of tuberculosis (TB) in humans. Humans are the only reservoir for the bacterium. Mycobacterium bovis is the etiologic agent of TB in cows and rarely in humans. Both cows and humans can serve as reservoirs. Humans can also be infected by the consumption of unpasteurized milk. This route of transmission can lead to the development of extrapulmonary TB, exemplified in history by bone infections that led to hunched backs. Other human pathogens belonging to the Mycobacterium genus include Mycobacterium avium which causes a TB-like disease especially prevalent in AIDS patients, and Mycobacterium leprae, the causative agent of leprosy. Mycobacterium tuberculosis is a fairly large non-motile rod-shaped bacterium distantly related to the Actinomycetes. Many non pathogenic mycobacteria are components of the normal flora of humans, found most often in dry and oily locales. The rods are 2-4um in length and 0.2-0.5um in width. Mycobacterium tuberculosis is an obligate aerobe. For this reason, in the classic case of tuberculosis, the M.TB. complexes are always found in the well-aerated upper lobes of the lungs.
Catalog #	M9699-62
Applications	Suitable for use in Immunohistochemistry Immunoelectrophoresis and Immunofluorescence. Other applications have not been tested.
Recommended Dilution	Immunohistochemistry: Paraffin Sections
	Optimal dilutions to be determined by the researcher.
Storage and Stability	May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
CAS Number	n/a
Clone Type	Polyclonal
Isotype	IgG
Host	Rabbit
Concentration	~4-5mg/ml
Form	Supplied as a liquid PBS, pH 7.2, 0.1% sodium azide. No stabilizing proteins have been added.
Purity	Purified by Protein A affinity chromatography.
Immunogen	Purified PPD. PPD is generated by boiling a culture of Mycobacterium tuberculosis, specifically Old Tuberculin (OT).
Specificity	Recognizes Mycobacterium tuberculosis. Minimum of 2 major M. tuberculosis bands by immunoelectrophoresis (gamma & beta). This antibody has not been absorbed and may react with related microorganisms. Reactive with other Mycobacteria species including M. avium, M. phlei, and M. parafortuitum. Non reactive with E. coli K12, Salmonella typhimurium, Pseudomonas aeruginosa, Streptococcus (group B), Candida albicans and Neisseria meningitidis.
Important Note	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.