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You are here:Home » Antibodies » Abs to Adapter Proteins » Anti -MyD88 (Myeloid Differentiation Marker 88, Myeloid Differentiation Primary Response Gene (88), Myeloid Differentiation Primary Response Protein MyD88, MYD88D)

Anti -MyD88 (Myeloid Differentiation Marker 88, Myeloid Differentiation Primary Response
Gene (88), Myeloid Differentiation Primary Response Protein MyD88, MYD88D)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IH
MyD88, originally isolated as myeloid differentiation primary response gene, is expressed in a variety of tissues. MyD88 serves as a cytoplasmic adaptor protein involved in the signaling of TLR and IL-1R family members. It associates with and recruits IRAK to IL-1R complex in response to IL-1. This pathway leads to activation of NF-kB. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18. MyD88 deficient mice lack a response to LPS (a bacterial product) which employs toll like receptors 2 and 4 (TLR2 and zSTLR4) as signaling receptors.
Catalog #M9755-10W
ApplicationsSuitable for use in Western Blot and Immunohistochemistry. Other applications not tested.
Recommended DilutionWestern Blot: 5ug/ml
Immunohistochemistry (Formalin fixed paraffin embedded): 5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, 0.02% sodium azide.
PurityPurified by Protein G affinity chromatography.
ImmunogenSynthetic peptide corresponding to aa233-248 from human MYD88 (KLH).
SpecificityRecognizes human MYD88. Species sequence homology: Mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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