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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin-Associated Glycoprotein, Small/Large (S/L-MAG)

Anti -Myelin-Associated Glycoprotein, Small/Large (S/L-MAG)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Affinity Purified B IP IF
The Myelin-Associated Glycoprotein (MAG) is a minor constituent of the myelin sheath in the central nervous system (CNS) and the peripheral nervous system (PNS). MAG is a member of the immunoglobulin superfamily and shares significant homology with the neural cell adhesion molecule (N-CAM). In rat there are two isoforms of MAG that are the result of alternative splicing of the primary MAG. Large-MAG (L-MAG) has been identified as the functionally relevant isoform in the central nervous system, while small-MAG (S-MAG) maintains the integrity of myelinated fibers in the peripheral nervous system. L-MAG has a non-glycosylated mass of 72kDa, whereas the glycosylated form has an apparent molecular weight of 100kD Small-MAG (S-MAG) has a non-glycosylated apparent molecular weight of 67kD. MAG is an inhibitor of axon regeneration and has an important role in maintaining a stable interaction between axons and myelin. Early loss of MAG in the development of multiple sclerosis plaques suggests its role in the pathogenesis of this disease.
Catalog #M9757-50B
ApplicationsSuitable for use in Western Blot, Immunoprecipitation and Immunofluorescence. Other applications have not been tested.
Recommended DilutionWestern Blot: 1-3ug/ml
Immunoprecipitation: 1-3ug/IP reaction
Immunofluorescence: 10-30ug/ul
Optimal dilutions to be determined by the researcher.
Positive ControlRat brain homogenates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
Concentration~0.25mg/ml
FormSupplied as a liquid in PBS, pH 7.4, 0.1% sodium azide.
PurityPurified by immunoaffinity chromatography.
ImmunogenHuman S/L-MAG fusion protein with a C-terminal region insert.
SpecificityRecognizes the shared C-terminal region of the small and large myelin-associated glycoprotein. Species Crossreactivity: Rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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