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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin Basic Protein, aa130-136 (MBP)

Anti -Myelin Basic Protein, aa130-136 (MBP)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Affinity Purified E B IH
Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles. MBP serves as a marker for oligodendrocytes and Schwann cells. MBP is also a marker for malignant schwannomas and appears to play a significant role in the etiology of multiple sclerosis and experimental autoimmune encephalomyelitis.
Catalog #M9758-01
ApplicationsSuitable for use in ELISA, Western Blot, Immunohistochemistry and quantification of myelin basic protein. Other applications have not been tested.
Recommended DilutionsELISA: 10-20ug/ml
Western Blot: 1-2ug/ml
Immunohistochemistry (Frozen, paraffin): 3-5ug/ml
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2b
Clone No1.B.645
HostMouse
SourceHuman
Concentration~0.5mg/ml
FormSupplied as a liquid in PBS, pH 7.4. No preservatives added.
PurityPurified by Protein G affinity chromatography.
ImmunogenPurified human myelin basic protein.
SpecificityRecognizes residues 130-136 in human myelin basic protein (21.5kD and 18.5kD molecular forms).
Species CrossreactivityPrimate, rabbit, sheep, goat, rat and mouse.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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