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Anti -MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein)
Anti -MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic
Protein)
Pricing
For pricing information, USA customers sign in. Outside USA? Please contact your distributor for pricing. Specifications
| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rat |
Supernatant |
E B IH RIA |
|
| The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) found in bone marrow and the immune system may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. | | | Catalog # | M9758-01G1 | | Applications | Suitable for use in ELISA, Western Blot, RIA and Immunohistochemistry. Other applications not tested. | | Recommended Dilution | Immunohistochemistry (Formalin fixed paraffin embedded): 1:50 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 12 | | Host | Rat | | Source | Bovine | | Concentration | Not determined | | Form | Supplied as a liquid, 0.09% sodium azide. | | Purity | Supernatant | | Immunogen | Bovine MBP (aa82-87) | | Specificity | Reacts with bovine myelin basic protein from a wide range of species. Reacts weakly with peptides ending in the Phe 91 where the 91-92 Phe-Phe bond is broken. Species sequence homology: chicken, guinea pig, human, mammal, mouse, porcine, rabbit, rat and sheep. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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