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You are here:Home » Antibodies » Abs to Myelin » Anti -MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein)

Anti -MBP (Myelin Basic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic
Protein)

Pricing

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Specifications

Clone Host Grade Applications
Monoclonal Rat Supernatant E B IH RIA
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) found in bone marrow and the immune system may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells.
Catalog #M9758-01G1
ApplicationsSuitable for use in ELISA, Western Blot, RIA and Immunohistochemistry. Other applications not tested.
Recommended DilutionImmunohistochemistry (Formalin fixed paraffin embedded): 1:50
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No12
HostRat
SourceBovine
ConcentrationNot determined
FormSupplied as a liquid, 0.09% sodium azide.
PuritySupernatant
ImmunogenBovine MBP (aa82-87)
SpecificityReacts with bovine myelin basic protein from a wide range of species. Reacts weakly with peptides ending in the Phe 91 where the 91-92 Phe-Phe bond is broken. Species sequence homology: chicken, guinea pig, human, mammal, mouse, porcine, rabbit, rat and sheep.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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