Anti -Myelin Basic Protein (MBP, GDB, Golli MBP, Hemopoietic MBP, HMBPR, HUGO, MGC99675,
Myelin Deficient, MLD, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein,
Shiverer, SHI, SP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Rabbit |
Supernatant |
E B IP IC FC |
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| Myelin basic protein (MBP) is an intracellular protein with highly flexible structure found in myelin of central and peripheral nervous system (CNS, PNS). The classic group of MBP isoforms (isoforms 4-14) with PLP is the major protein components of the myelin membrane in CNS and functions in its formation and stabilization. The non-classic group of MBP isoforms (isoforms 1-3/Golli-MBPs) has been implicated in early developing brain long before myelination, possible components of transcriptional complexes, and possible role in T-cells and neural cells signaling pathways. MBP is often post-translationally modified in various ways, which includes citrullination, N-terminal acylation, deamidation, and phosphorylation (1). Surface charge reduction of citrullinated and/or methylated MBP has been linked in weakening the myelin membrane, which can lead to demyelinating diseases such as chronical multiple sclerosis (MS) (2). | | | Catalog # | M9758-01N | | Applications | Suitable for use in Flow Cytometry, Western Blot, Immunoprecipitation and Immunocytochemistry. Other applications not tested. | | Recommended Dilution | Flow Cytometry: 1:60 | | Western Blot: 1:1000-1:5000 | | Immunoprecipitation: 1:20 | | Immunocytochemistry: 1:100-1:250 | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG | | Clone No | 9H478 | | Host | Rabbit | | Source | Human | | Concentration | Not determined | | Form | Supplied as a liquid in 50mM Tris-Glycine, pH 7.4, 0.15M sodium chloride, 40% glycerol, 0.01% sodium azide, 0.05% BSA. | | Purity | Supernatant | | Immunogen | Synthetic peptide corresponding to residues located between amino acids 150 to 185 of human MBP. | | Specificity | Recognizes human MBP. Species Crossreactivity: Mouse and rat. | | | Important Note | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological. |
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Download Specifications for Anti -Myelin Basic Protein (MBP, GDB, Golli MBP, Hemopoietic MBP, HMBPR, HUGO, MGC99675, Myelin Deficient, MLD, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein, Shiverer, SHI, SP) |
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