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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin Basic Protein, aa119-131 (MBP)

Anti -Myelin Basic Protein, aa119-131 (MBP)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E B IC
Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles (3). MBP serves as a marker for oligodendrocytes and Schwann cells (3). MBP is also a marker for malignant schwannomas (4) and appears to play a significant role in the etiology of multiple sclerosis (57) and experimental autoimmune encephalomyelitis (8).
Catalog #M9758-03G
ApplicationsSuitable for use in Immunocytochemistry, ELISA and Western Blot. Other applications have not been tested.
Recommended DilutionImmunocytochemistry: Frozen sections
Western Blot 10ug/ml.
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and add glycerol (40-50%). Freeze at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Clone TypeMonoclonal
IsotypeIgG1
Clone No2Q288
HostMouse
SourceBovine
Concentration~10-50ug/ml
FormSupplied as a liquid in 0.2M Tris/HCl, pH 7.4, 5-10% fetal calf serum, 0.09% sodium azide.
PurityTissue culture supernatant
ImmunogenBovine myelin basic protein
SpecificityReacts with MBP from human, bovine, rabbit, rat, sheep and guinea pig. The epitope appears to be located in the region of residues 119-131.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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