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Anti -Myelin Basic Protein, aa129-138 (MBP)
Anti -Myelin Basic Protein, aa129-138 (MBP)
Pricing
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| Clone |
Host |
Grade |
Applications |
| Monoclonal |
Mouse |
Supernatant |
E B RIA |
|
| Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles (3). MBP serves as a marker for oligodendrocytes and Schwann cells (3). MBP is also a marker for malignant schwannomas (4) and appears to play a significant role in the etiology of multiple sclerosis (5–7) and experimental autoimmune encephalomyelitis (8). | | | Catalog # | M9758-03H | | Applications | Suitable for use in Immunohistochemistry, Immunoblotting, Western blotting, ELISA and RIA. Other applications have not been tested. | | Recommended Dilution | Immunohistochemistry: 1:10. Frozen sections | | Optimal dilutions to be determined by the researcher. | | Storage and Stability | May be stored at 4°C for short-term only. For long-term storage, store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. | | CAS Number | n/a | | Clone Type | Monoclonal | | Isotype | IgG2a | | Clone No | 2Q289 | | Host | Mouse | | Source | Bovine | | Concentration | Not determined | | Form | Supplied as a liquid in 0.2M Tris/HCl, pH 7.4, 5-10% fetal calf serum, 0.1% sodium azide. | | Purity | Supernatant | | Immunogen | Bovine myelin basic protein. | | Specificity | Reacts with MBP from human, bovine and rat, epitope 129–138. Reacts weakly with rabbit. Does not react with guinea pig. | | | Important Note | This product is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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