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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin Basic Protein, aa129-138 (MBP)

Anti -Myelin Basic Protein, aa129-138 (MBP)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Supernatant E IH
Myelin basic protein (MBP) is a single-chain, flexible polypeptide of about 18.5kD existing in its natural environment as an extrinsic and loosely bound component of the cytoplasmic portion of the myelin membrane sandwich. Ultrastructural immunocytochemistry with anti-myelin basic protein has shown that MBP is localized in the compact myelin sheath. MBP has not been demonstrated in rough endoplasmic reticulum, lysosomes or any other cytoplasmic organelles. MBP serves as a marker for oligodendrocytes and Schwann cells. MBP is also a marker for malignant schwannomas and appears to play a significant role in the etiology of multiple sclerosis and experimental autoimmune encephalomyelitis.
Catalog #M9758-03T
ApplicationsSuitable for use in ELISA, Immunohistochemistry and Western Blot. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry (frozen): 1:10
ELISA: 1:200-1:1000
Optimal dilutions to be determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgG2a
Clone No3H2754
HostMouse
SourceBovine
ConcentrationNot determined
FormSupplied as a liquid in 0.2M Tris HCl pH 7.4, 5-10% fetal calf serum, 0.09% sodium azide.
PuritySupernatant
ImmunogenBovine Myelin Basic Protein (MBP)
SpecificityRecognizes bovine Myelin Basic Protein. Reactive with an epitope in the aa129-138 region of the human MBP molecule.
Species CrossreactivityHuman, rat
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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