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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin and Oligodendrocytes (CNS)

Anti -Myelin and Oligodendrocytes (CNS)

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Specifications

Clone Host Grade Applications
Monoclonal Mouse Ascites IH IC
This protein is found exclusively on oligodendrocytes and myelin in the central nervous system (CNS). Myelin is produced by oligodendrocytes in the CNS and Schwann cells in the peripheral nervous system (PNS). Defining the differences between CNS and PNS myelin may provide insights into the process of myelination and the pathogenesis of certain idiopathic diseases involving myelin such as multiple sclerosis, certain leukodystrophies, and other myelinopathies. On de-myelination, immunoreactivity for MOSP, like MBP, is lost.
Catalog #M9758-07A
ApplicationsSuitable for use in Immunocytochemistry and Immunohistochemistry. Not recommened for use in Western Blot. Other applications have not been tested.
Recommended DilutionsImmunohistochemistry: 1:1000-1:5000
Optimal dilution determined by the researcher.
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypeMonoclonal
IsotypeIgM
Clone No2Q91
HostMouse
SourceRat
ConcentrationNot Determined
FormSupplied as a liquid in PBS. No preservatives added.
PurityAscites
ImmunogenRat glial membranes and whole brain white matter.
SpecificityRecognizes rat Myelin and Oligodendrocytes. Stains oligodendrocytes in neonatal rat glia. Does not crossreact with type 1 astrocytes, type 2 astrocytes or fibroblasts. Does not stain cultures of rat Schwann cells. Does not label peripheral myelin. Labels oligodendrocytes and CNS myelin in tissue sections. Species Crossreactivity: human, chick, mouse, ferret, feline and monkey.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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