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You are here:Home » Antibodies » Abs to Myelin » Anti -Myelin Basic Protein, Dimethyl (Arg107)

Anti -Myelin Basic Protein, Dimethyl (Arg107)

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Specifications

Clone Host Grade Applications
Polyclonal Rabbit Serum B
Myelin basic protein (MBP) is the major extrinsic membrane protein of central nervous system. MBP is believed to be important in the process of myelination of nerves in the central nervous system (CNS). MBP was initially sequenced in 1979 after isolation from myelin membranes. Since that time, knockout mice deficient in MBP have been developed which showed decreased amounts of CNS myelination and a progressive disorder characterized by tremors, seizures, and early death. The gene for MBP is on chromosome 18; the protein localizes to the CNS and to various cells of the hematopoietic system. The pool of MBP in the central nervous system is very diverse. Not only is MBP present in a number of splice varients, but the protein also undergoes a variety of post-translational modifications, and exists in the CNS in a number of forms (i.e. phosphorylated, methylated, deamidated and citrullinated).
Interest in MBP has centered on its role in demyelinating diseases, particularly multiple sclerosis (MS). Several studies have shown a role for antibodies against MBP in the pathogenesis of MS. Some studies have linked a genetic predisposition to MS to the MBP gene, though a majority have not.
Catalog #M9758-08J
Applications
Suitable for use in Western Blot. Other applications not tested.
Recommended DilutionWestern Blot: 1:1000
Optimal dilutions to be determined by the researcher.
Positive ControlMouse MBP knockout and wildtype thymus lysates
Storage and StabilityMay be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Clone TypePolyclonal
IsotypeIgG
HostRabbit
SourceMouse
ConcentrationNot determined.
FormSupplied as a liquid in 0.05% sodium azide.
PuritySerum
ImmunogenLinear peptide corresponding to the C-terminus of MBP dimethylated at Arg107.
SpecificityRecognizes MBP dimethylated at Arg107. Species sequence homology: human, rat.
Important NoteThis product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.


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